Allergic reaction. A prolactinoma is a benign (non-cancerous) tumor that forms in your pituitary gland and causes excess production of prolactin. Besides changes in menstrual bleeding patterns, other common side effects reported in women using NEXPLANON include: headaches; vaginitis (inflammation of the vagina); weight gain; acne; breast pain; viral infection such as sore throats or flu-like symptoms; stomach pain; painful periods; mood swings, nervousness, or depressed mood; back pain; nausea; dizziness; pain and pain at the site of insertion. Symptoms of high prolactin levels include irregular periods, loss of sex drive, sexual dysfunction, heavy menstrual bleeding, weight gain, anxiety, depression, and psychosis. Pain. Here's how to. Prolactin suppresses GnRH, causing a decrease in luteinizing hormone and follicle-stimulating hormone, ultimately leading to decreased serum testosterone levels and hypogonadism. Talk with your doctor to determine which kind of contraceptive is best for you. If you have questions about possible side effects, talk with your doctor. Source: Obstetrics and Gynecology. Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder. You have an increased chance of getting blood clots during surgery or bed rest. If the patient's hyperprolactinemia is symptomatic, treatment strategies include switching to an alternative medication that does not cause hyperprolactinemia, using estrogen or testosterone replacement, or, rarely, cautiously adding a dopamine agonist. Pregnancy. More about ranitidine and hyperprolactinaemia [letter]. But its not known how much of the weight gain was due to Nexplanon. Prolactin is a stress hormone that increases in response to a number of physiologic and stressful conditions. However, in men it can cause erectile dysfunction . Cysts may develop on the ovaries and usually go away without treatment, but sometimes surgery is needed to remove them. Lack of adverse interactions between concomitantly administered selegiline and citalopram. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. It can be a normal occurrence due to [10, 11]:Pregnancy; Breastfeeding; Breast and nipple stimulation; Stress; Medications, pituitary tumors, and other diseases can cause abnormal hyperprolactinemia, which may require medical attention [].1) Pregnancy and Breastfeeding Call your doctor for medical advice about side effects. An eating disorder called anorexia. You can opt to never have a period or to have a, There are many birth control options and picking the one thats best for you can be a challenge. In most cases, the side effects subside after a few months. Hormonal birth control increases the risk of gallbladder disease. A single, thin rod measuring 1.6 inches long, about the size of a matchstick, Nexplanon is discreet. Neuroleptic-associated hyperprolactinemia: can it be treated with bromocriptine?. If you become pregnant during your Nexplanon treatment, be sure to tell your doctor right away. Seizures can cause a transient increase in prolactin. To learn more, see the Does Nexplanon cause weight gain? section below. Theyll likely remove the Nexplanon implant. 1. Dizziness. For information about the difference between sex and gender, see this article. In men, high prolactin levels can cause: Milky . Although uncommon, its possible to have serious side effects with Nexplanon. About 40 percent of people with hypothyroid, or underactive . Again, all such medication changes must be done under the supervision of the patient's psychiatrist, and consideration must be given to other potential adverse effects of these alternative medications. Oral contraception is a safe, effective way to prevent pregnancy and relieve period pain. signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools) symptoms of a urinary tract infection (e.g. They may be able to recommend ways to help manage your weight. In some cases, they may recommend a different birth control option for you. (1) mildly increased prolactin levels (400-600mu/L) may be physiological and asymptomatic but higher levels are usually pathological should be repeated to confirm hyperprolactinaemia; very elevated levels (above 5,000mu/L) usually imply a prolactin-secreting pituitary tumour Although these side effects werent reported in studies, theyve been reported by people who got Nexplanon after it was approved for use. They may monitor your mood more closely during your Nexplanon treatment. Hyperprolactinaemia during famotidine therapy [letter]. Hyperprolactinaemia develops in patients taking antipsychotics such as risperidone. Tell your healthcare provider at least 4 weeks before if you are going to have surgery or will need to be on bed rest. Use a backup birth control method and call your healthcare provider right away if the implant comes out. Nexplanon is commonly known as the birth control implant. If you smoke and want to use NEXPLANON, you should quit. serious depression, and. Its possible that Nexplanon may cause low libido. Its used to help prevent pregnancy, so it shouldnt be inserted if youre already pregnant. Effect of chronic metoclopramide therapy on serum pituitary hormone concentrations. Nexplanon (etonogestrel) can cause some serious health issues. (With spotting, you have light bleeding that happens outside of your regular period.) What are the more common side effects of Nexplanon? Low estrogen oral contraceptives and the hypothalamo-pituitary axis. To ensure NEXPLANON is properly inserted, immediately after insertion, you and your healthcare provider will feel for the implant under your skin. Regarding some of the other antidepressants, PRL level elevations have not been seen with long-term use of nefazodone. They can determine whether Nexplanon may be the cause. The hypothalamus predominantly influences PRL secretion through 1 or more PRL inhibitory factors that reach the pituitary via the hypothalamic/pituitary portal vessels. Symptoms from the high prolactin levels include discharge of milk from the breast (galactorrhoea) and breast tenderness. Its important to note that Nexplanon may decrease milk production, which may make breastfeeding more difficult. The use of NEXPLANON may also increase your chance of serious blood clots, especially if you have other risk factors, such as smoking. This is not a complete list of possible side effects. Symptoms of mood changes or depression may include: If you experience depression or other changes in mood with Nexplanon, tell your doctor. Although they werent common, these side effects were reported in people who had Nexplanon inserted or removed in studies. Do not drive or operate heavy machinery . Your doctor may recommend monitoring your blood sugar more often during your Nexplanon treatment. Mechanism of verapamil calcium channel blockade-induced hyperprolactinemia. * In this article, we use the term female to refer to someones sex assigned at birth. US-XPL-116452 10/22. To learn more, see the Side effects of Nexplanon insertion and removal section below. Pattern of development of hyperprolactinemia after initiation of haloperidol therapy. In some cases, they may be a sign of a different condition, such as pregnancy, or in rare cases, cancer. Serum prolactin levels in schizophreniaeffect of antipsychotic drugs: a preliminary report. The implant and low libido. Sertraline treatment does not increase plasma prolactin levels in healthy subjects [letter]. Relation of serum molindone levels to serum prolactin levels and antipsychotic response. Symptoms of a prolactinoma relate to the high prolactin levels in the blood. You'll be asked to wait a few minutes as the area begins to numb up. ORGANON and the ORGANON Logo are trademarks of the Organon group of companies. A study found that there is a connection to higher prolactin in the luteal phase from lower progesterone levels. Yes, Nexplanon may cause long-term changes in your period bleeding. Because of its association with cardiac dysrhythmias, cisapride is no longer available in the United States. These are known as drug-condition interactions. But if prolactin level is more than 100, it may be due to a serious medical disorder such as pituitary tumor. Can you change my dose of Nexplanon to relieve side effects that Im experiencing? It is important to ensure that hyperprolactinemia in an individual patient is due to medication and not to a structural lesion in the hypothalamic/pituitary area. In most cases, these side effects should be temporary. Confirm that the medication is the cause of hyperprolactinemia. Some of these causes are physiologic and others pathologic. 2023 Organon group of companies. It's also called Nexplanon and there's a slightly older version called Implanon. Examples include: If your doctor confirms youve had a mild allergic reaction to Nexplanon, theyll decide whether you should continue your treatment. If you experience any other breast-related side effects, tell your doctor. call your doctor immediately if you have , yellowing of your skin or whites of your eyes, Especially with fever, tiredness, loss of appetite, dark-colored urine, or light-colored bowel movements, Anything severe that is painful, swollen, or tender to the touch in the lower stomach, Or lack of energy, tiredness, or you feel very sad. Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. Nexplanon is a prescription drug thats used to help prevent pregnancy. Unusual vaginal bleeding or lower stomach (abdominal) pain may be a sign of ectopic pregnancy. Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients. You can learn more about how we ensure our content is accurate and current by reading our. The active ingredient in Nexplanon is etonogestrel. If you don't remember your password, you can reset it by entering your email address and clicking the Reset Password button. Keep reading to learn about the common, mild, and serious side effects that the Nexplanon implant can cause. In men, high prolactin levels can cause galactorrhea, impotence (inability to have an erection during sex), reduced desire for sex, and infertility. As a result, hyperprolactinemia results almost exclusively from diseases that cause hypersecretion of prolactin by lactotroph cells. This phase of the cycle can be what causes high prolactin levels. 0 = no effect; = minimal increase but not to abnormal levels; + = increase to abnormal levels in small percentage of patients; ++ = increase to abnormal levels in 25% to 50% of patients; +++ = increase to abnormal levels in more than 50% of patients. Management of prolactinomas during pregnancy. The effects of atypical antipsychotics on serum prolactin levels. Heterogeneous distribution of serum prolactin values in apparently healthy young women, and the effects of oral contraceptive medication. If you experience nausea with Nexplanon, talk with your doctor. For most women, the implantation of Nexplanon is fast and painless. The phase IV clinical study analyzes which people take Implanon and have Blood prolactin increased. A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning. In such circumstances, either the medication should be stopped temporarily to determine whether PRL levels return to normal or the drug should be switched to one that does not cause hyperprolactinemia. Your arm will be sterilized first, then a local anesthetic will be applied. Nexplanon may raise your triglyceride or cholesterol levels. Ask them what other medications are better options for you. You should not use NEXPLANON if you are pregnant or think you may be pregnant; have or have had blood clots. To learn more about spotting or other changes in period bleeding, see the Side effects explained section below. Stress - Elevated prolactin levels may occur due to a lot of mental stress. It's a type of pituitary adenoma. Incidence of hyperprolactinemia during oral contraceptive therapy. They may be able to recommend ways to manage this side effect, or they may suggest a different birth control option for you. Serum-prolactin in patients receiving chronic oral cimetidine [letter]. News and Views. Your doctor will recommend a different kind of birth control for you. The effect of fluvoxamine on serum prolactin and serum sodium concentrations: relation to platelet 5-HT. Special procedures, including surgery in the hospital, may be needed to remove the implant. Galactorrhea and hyperprolactinemia associated with protease inhibitors [letter]. Some people in studies had the Nexplanon implant removed due to weight gain. In studies, 1 in 10 women stopped using NEXPLANON because of an unfavorable change in their bleeding pattern. For more information, ask your healthcare provider for advice about any side effects that concern you. In 1 study, fluoxetine was given at a dosage of 60 mg/d for 6 days to 7 healthy women, and their mean SD PRL levels increased from 9.61.6 g/L to 11.11.7 g/L (16%). Anterior pituitary hormone responses to a kappa-opioid agonist in man. It releases the hormone progestin to stop you from getting pregnant. These medicines will be used when the implant is placed into or removed from your arm. Talk to your healthcare provider about using NEXPLANON if you have diabetes, high cholesterol or triglycerides, headaches, gallbladder or kidney problems, history of depressed mood, high blood pressure, allergy to numbing medicines (anesthetics) or medicines used to clean your skin (antiseptics). But alcohol may make certain side effects of Nexplanon worse. 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