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1985 Apr; 5(4):684-91. Gut. Molecular and cellular biology of the small intestine. Introducing PNAS Nexus. 2020 12; 72(6):2182-2196. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Techniques to measure nucleic acid-protein binding and specificity. J Clin Invest. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. 1999 03; 276(3):G591-8. 2014 Oct 28; 83(18):1653-60. Gastroenterology. Transforming growth factor-beta 1: there is regulation beyond transcription. Gut. 2003 Apr; 37(4):833-41. 2017 Jun 16; 7:314-323. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. J Biol Chem. 2019 09; 71(3):573-585. Therapeutic strategies for hepatic fibrosis. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. J Clin Invest. Proud to be part of UC San Diego and UC San Diego 1994 Dec; 124(6):755-60. 1984; 49:151-60. 2003 Feb; 37(2):267-76. 1997 Sep; 17(9):5201-9. J Clin Invest. 2010 Oct; 8(10):891-8, 898.e1-2. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Am J Physiol. Hepatology. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. 2003 Sep; 285(3):G642-51. 1993 May 15; 53(10 Suppl):2279-86. Semin Liver Dis. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. 2007 Aug; 47(2):307-9. Hepatology. 2000 Dec; 32(6):1272-9. 2011 Jan; 53(1):96-105. Hepatology. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Interactions between the intestinal microbiome and liver diseases. 1999 Mar; 31(2):173-9. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2014 Aug 12; 111(32):E3297-305. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. 2021 07 20; 118(29). Amyotroph Lateral Scler Frontotemporal Degener. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. J Biol Chem. 2004 May 28; 279(22):23822-9. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Migration of fibrocytes in fibrogenic liver injury. Gastroenterology. Proc Natl Acad Sci U S A. J Clin Invest. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Cancer Res. 2020; 11:370. Cell Death Differ. Mol Cell Biol. 2015 Apr 06; 212(4):469-80. 1995 Sep; 9(9):1157-65. Liver Int. The future of gastroenterology and gastroenterology. Hepatology. 2004 Jun; 40(6):942-51. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Gastroenterology. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). 2013; 8(2):e56116. 1998 Feb 15; 101(4):802-11. Promising Therapy Candidates for Liver Fibrosis. J Hepatol. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Gastroenterology. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. 2002 Mar; 82(3):323-33. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 2010 Feb 25; 3:39-47. 2000 Jul; 279(1):G100-6. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Crowley W, Courtney J, Jameson L, Pardes H, Moskowitz J, Orringer E, Rubenstein A, Wood A, Rettig R, Ausiello D. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. J Clin Gastroenterol. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. Nat Clin Pract Gastroenterol Hepatol. Alzheimer's disease: the vascular connection. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. David has 2 jobs listed on their profile. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. This graph shows the total number of publications by year. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Dig Dis Sci. 2005 Apr 08; 280(14):13374-82. 2006 Jul; 131(1):272-5. 2011 Dec; 17(4):251-7. Mol Ther Nucleic Acids. Cell Metab. Adv Second Messenger Phosphoprotein Res. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. J Clin Invest. 2021; 16(12):e0260721. Arch Biochem Biophys. 2017 Apr 03; 127(4):1254-1270. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. 2006 Jul; 86(7):676-86. 1991 Feb 01; 88(3):849-53. Hepatology. Current and prospective therapies for hepatic fibrosis. Nucleic Acids Res. NOX in liver fibrosis. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. 2011 Jul; 179(1):189-98. Proc Natl Acad Sci U S A. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. 2015 Nov-Dec; 49 Suppl 1:S25-7. 2013 Jul; 145(1):16-31. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. 1995 Jul; 22(1):241-51. J Cell Biol. 2010 Feb; 16(2):181-90. 1980 Apr 03; 302(14):765-9. 2020 12 15; 95(24):e3163-e3179. Fibrogenesis of parenchymal organs. 2008 Feb; 233(2):109-22. Hepatology. Gastroenterology. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! 2007 Dec 07; 249(3):518-31. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Alcohol Clin Exp Res. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 2002 Nov; 70(11):6294-301. PLoS One. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Mol Genet Genomic Med. J Gastroenterol. Alteration of interferon-a/ receptors in chronic hepatitis B patients. Hepatology. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. 1998 Sep; 13 Suppl:S39-50. J Stroke Cerebrovasc Dis. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, 1999; 66:205-22. 2003 Nov; 285(5):G949-58. Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA. Toxicol Sci. 1999 Nov; 20(11):2095-100. Cell Metab. J Biol Chem. Nature. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Mol Cell Biol. Hepatology. 2000 Dec; 279(6):G1333-42. 2010 Sep; 139(3):836-45, 845.e1. Circ Res. 2016; 7:47. J Hepatol. PLoS One. Surgery. J Gastroenterol Hepatol. Mol Cell Biol. 2006 Apr; 290(4):G583-9. J Clin Gastroenterol. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. 2002 Oct; 4(5):769-81. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Front Physiol. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. 2000 Jan; 48(1):39-44. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. PLoS One. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 2013 Dec; 58(6):1930-40. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Bone Miner Res. Cell Metab. Clin Res Hepatol Gastroenterol. Scelzo A, Di Somma S, Antonini P, Montross LP. 1997 10; 273(4):G795-803. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. 2008 Feb; 25(2):249-58. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. J Clin Invest. To return to the graph. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Dig Dis. Aliment Pharmacol Ther. Am J Respir Cell Mol Biol. The fecal microbiome of ALS patients. 2011 Jul; 41(7):683-6. 2019 03; 156(4):1156-1172.e6. NF-kappaB activation in Kupffer cells after partial hepatectomy. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. 2000 Mar-Apr; 21(2):135-41. 2000 Aug; 119(2):446-60. Hepatology. Proc Natl Acad Sci U S A. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Hepatology. I. TNF-induced liver injury. Am J Gastroenterol. 1999 Apr 15; 162(8):4447-54. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. J Hepatol. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Cloning of murine ferrochelatase. Fibrogenesis and type I collagen gene regulation. 1989 Jun 05; 264(16):9583-91. Moderate alcohol drinking: effects on the heart and liver. Liver Int. J Gastroenterol Hepatol. Alcohol Clin Exp Res. 2017 Feb 01; 312(2):C131-C143. Am J Physiol Gastrointest Liver Physiol. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. J Hepatol. 2012; 5(Suppl 1):S17. Best Pract Res Clin Gastroenterol. 1994 Sep; 14(9):5950-60. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Gastroenterology. J Gastroenterol Hepatol. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Liver Int. 2022 08; 42(3):233-249. Akt activation protects rat liver from ischemia/reperfusion injury. Clin Gastroenterol Hepatol. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Nucleic Acids Res. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. Science. Nat Rev Gastroenterol Hepatol. 2016 05; 139(Pt 5):e28. 2003 May; 37(5):1043-55. Trans Am Clin Climatol Assoc. Hepatology. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. 2013 02 15; 177(4):333-42. Compr Ther. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. Cell Metab. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. 2015 Feb; 4(1):34-47. 2008 Feb; 47(2):677-85. 2001 Jul; 34(1):89-100. 2019 03 29; 10(1):1406. 1994 Jun 21; 91(13):6030-4. 2010 Oct; 52(4):1390-400. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Carethers will report directly to the chancellor and is part of the leadership team. 2005 Apr; 115(4):849-59. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 2001 Nov; 34(5):953-63. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. J Biol Chem. 2015 Jul; 22(7):512-8. 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